Cornelius Concepts

The Browser-Safe Palette, as Linda Weinman, author of the site and several books, so named it, is the actual palette that Mosaic, Netscape, and Internet Explorer use within their browsers. The palettes used by these browsers are slightly different on Macs and PCs. This palette is based on math, not beauty.
The only reason to use the browser-safe palette is if you have a concern that your Web design work will be viewed from a 256 color (8-bit) computer system. Today, the justification for using the browser-safe palette has diminished greatly if you are developing your site for users who have current computer systems.
There may be resurgence in the need for the browser-safe palette when designing for alternative online publishing devices, such as cell phones and PDAs. Those systems are still in 1-bit (black and white) or 8-bit color. Right now, very few people are designing their web sites to work on those systems, so the need for the browser-safe color palette is definitely downgraded to a mere shadow of its former glory.